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The internal neuromodulation market in Saudi Arabia, South Africa, and Turkey is a fast emerging market. The growth of this market is driven by factors such as public initiatives to increase awareness, technological developments, growing demand for the use of advanced technologies, and the increasingly aging population. However, factors such as the disadvantages of a dearth of skilled professional and the reimbursement scenario restrain the growth of this market.

The report has been broadly classified into spinal cord stimulation, deep brain stimulation, sacral nerve stimulation, vagus nerve stimulation, and gastric electric neurostimulation. The spinal cord stimulator segment is further categorized on the basis of application into chronic pain, failed back surgery syndrome, ischemic pain, and others. Likewise, the deep brain stimulation market has its application in Parkinson’s disease, tremors, depression, and others that include chronic pain, dystonia, Tourette’s syndrome, and Alzheimer’s disease.

The sacral nerve stimulation market has applications in urinary incontinence and fecal incontinence. Vagus nerve stimulator comprises epilepsy and other applications; gastric stimulation includes gastroparaeisis and others. The gastric neurostimulator market segment is estimated to grow at the highest CAGR from 2014 to 2019. The drivers for this market are the increase in the number of people who suffer from severe GERD and gastroparesis. Most incidences of delayed

1 INTRODUCTION 9
11 OBJECTIVES OF THE STUDY 9
12 MARKET SEGMENTATION & COVERAGE 9
13 STAKEHOLDERS 10
2 RESEARCH METHODOLOGY 11
21 INTEGRATED ECOSYSTEM OF INTERNAL NEUROSTIMULATION/ NEUROMODULATION MARKET 11
22 ARRIVING AT THE neuromostimulation/neuromodulation MARKET SIZE 12
221 MARKET SHARE 12
222 TOP-DOWN APPROACH 12
3 EXECUTIVE SUMMARY 13
4 MARKET OVERVIEW 15
41 INTRODUCTION 15
42 INTERNAL NEUROSTIMULATION/NEUROMODULATION MARKET: COMPARISON WITH PARENT MARKET 15
43 MARKET DRIVERS and INHIBITORS 17
5 INTERNAL NEUROSTIMULATION/NEUROMODULATION MARKET, BY MODALITY 20
51 INTRODUCTION 20
52 SPINAL CORD STIMULATION 23
53 DEEP BRAIN STIMULATION 25
54 SACRAL NERVE STIMULATION 27
55 VAGUS NERVE STIMULATON 29
56 GASTRIC ELECTRICAL STIMULATION (GES) 30
6 INTERNAL NEUROSTIMULATION/NEUROMODULATION MARKET,BY APPLICATION 33
61 INTRODUCTION 33
611 SPINAL CORD STIMULATION (SCS) MARKET, BY APPLICATION/ GEOGRAPHY 33
6111 Spinal Cord Stimulation (SCS) Market, by Application 34
6112 Spinal Cord Stimulation (SCS) Market, by Geography 37
612 DEEP BRAIN STIMULATION (DBS) MARKET, BY APPLICATION/ GEOGRAPHY 40
6121 Deep Brain Stimulation (DBS) Market, by Application 41
6122 Deep Brain Stimulation (DBS) Market, by Geography 44
613 SACRAL NERVE STIMULATION (SNS) MARKET, BY APPLICATION/ GEOGRAPHY 47
6131 Sacral Nerve Stimulation (SNS) Market, by Application 48
6132 Sacral Nerve Stimulation (SNS) Market, by Geography 51
614 VAGUS NERVE STIMULATION (VNS) MARKET, BY APPLICATION/GEOGRAPHY 53
6141 Vagus Nerve Stimulation (VNS) Market, by Application 54
6142 Vagus Nerve Stimulation (VNS) Market, by Geography 57
615 GASTRIC ELECTRICAL STIMULATION (GES) MARKET, BY APPLICATION/ GEOGRAPHY 58
6151 Gastric Electrical Stimulation (GES) Market, by Application 59
6152 Gastric Electrical Stimulation (GES) Market, by Geography 62
7 INTERNAL NEUROSTIMULATION/NEUROMODULATION MARKET: COMPETITIVE LANDSCAPE 63
71 Company share analysis: by Modality 63
711 SPINAL CORD STIMULATION 63
712 DEEP BRAIN STIMULATION 65
713 SACRAL NERVE STIMULATION 66
714 VAGUS NERVE STIMULATION 66
72 COMPANY PRESENCE IN internal neurostimulation/ neuromodulationMARKET 68
8 INTERNAL NEUROSTIMULATION/NEUROMODULATION MARKET, BY COMPANY 69
81 BOSTON SCIENTIFIC CORPORATION (US) 69
111 OVERVIEW 69
112 KEY FINANCIALS: 69
113 PRODUCT AND SERVICE OFFERINGS 70
114 RELATED DEVELOPMENTS 70
82 CERBOMED GMBH (GERMANY) 71
821 OVERVIEW 71
822 KEY FINANCIALS 71
823 PRODUCT AND SERVICE OFFERINGS 71
83 CYBERONICS, INC (US) 72
831 OVERVIEW 72
832 KEY FINANCIALS 72
833 PRODUCT AND SERVICE OFFERINGS 72
84 ENTEROMEDICS, INC (US) 73
841 OVERVIEW 73
842 KEY FINANCIALS 73
843 PRODUCT AND SERVICE OFFERINGS 73
85 MEDTRONIC, INC (US) 74
851 OVERVIEW 74
852 KEY FINANCIALS 74
853 PRODUCT AND SERVICE OFFERINGS 75
854 RELATED DEVELOPMENTS 76

86 ST JUDE MEDICAL (US) 77
861 OVERVIEW 77
862 KEY FINANCIALS 77
863 PRODUCT AND SERVICE OFFERINGS 78
864 RELATED DEVELOPMENTS 79
87 SYNAPSE BIOMEDICAL, INC (US) 80
871 OVERVIEW 80
872 KEY FINANCIALS 80
873 PRODUCT AND SERVICE OFFERINGS 80
88 UROPLASTY, INC (US) 81
881 OVERVIEW 81
882 KEY FINANCIALS 81
883 PRODUCT AND SERVICE OFFERINGS 81
9 APPENDIX 82
91 CUSTOMIZATION OPTIONS 82
911 PRODUCT ANALYSIS 82
912 EPIDEMIOLOGY DATA 82
913 SURGEONS/PHYSICIANS PERCEPTION ANALYSIS 82
914 REGULATORY FRAMEWORK 82
92 RELATED REPORTS 83
93 INTRODUCING RT: REAL-TIME MARKET INTELLIGENCE 83
931 SNAPSHOTS 84

LIST OF TABLES

TABLE 1 GLOBAL INTERNAL NEUROSTIMULATION/NEUROMODULATION MARKET: COMPARISON WITH PARENT MARKET, 2012 – 2019 (USD MILLION) 16
TABLE 2 INTERNAL NEUROMODULATION/NEUROSTIMULATION MARKET,BY GEOGRAPHY, 2012 – 2019 (USD THOUSAND) 17
TABLE 3 INTERNAL NEUROMODULATION/NEUROSTIMULATION MARKET IN SAUDI ARABIA, SOUTH AFRICA, AND TURKEY: DRIVERS AND INHIBITORS 17
TABLE 4 INTERNAL NEUROSTIMULATION/NEUROMODULATION MARKET IN SOUTH AFRICA, BY MODALITY, 2013 - 2019 (USD THOUSAND) 20
TABLE 5 INTERNAL NEUROSTIMULATION/NEUROMODULATION MARKET IN TURKEY, BY MODALITY, 2012 – 2019 (USD THOUSAND) 21
TABLE 6 INTERNAL NEUROSTIMULATION/NEUROMODULATION MARKET IN SAUDI ARABIA, BY MODALITY, 2012 – 2019 (USD THOUSAND) 22
TABLE 7 SPINAL CORD STIMULATION MARKET, BY GEOGRAPHY,2013–2019 (USD THOUSAND) 24
TABLE 8 DEEP BRAIN STIMULATION MARKET, BY GEOGRAPHY,2012–2019 (USD THOUSAND) 26
TABLE 9 SACRAL NERVE STIMULATION MARKET, BY GEOGRAPHY,2013–2019 (USD THOUSAND) 28
TABLE 10 VAGUS NERVE STIMULATIONMARKET, BY GEOGRAPHY,2012–2019 (USD MN) 29
TABLE 11 GASTRIC ELECTRICAL STIMULATION MASKS MARKET, BY GEOGRAPHY,2013–2019 (USD THOUSAND) 31
TABLE 12 SPINAL CORD STIMULATION (SCS) MARKET IN SOUTH AFRICA, BY APPLICATION, 2012 – 2019 (USD THOUSAND) 35
TABLE 13 SPINAL CORD STIMULATION (SCS) MARKET IN TURKEY, BY APPLICATION,2012 – 2019 (USD THOUSAND) 36
TABLE 14 SPINAL CORD STIMULATION (SCS) MARKET IN SAUDI ARABIA, BY APPLICATION, 2012 – 2019 (USD THOUSAND) 37
TABLE 15 CHRONIC PAIN SEGMENT IN SPINAL CORD STIMULATION (SCS) MARKET,BY GEOGRAPHY, 2012 – 2019 (USD THOUSAND) 38
TABLE 16 FAILED BACK SURGERY SYNDROME SEGMENT IN SPINAL CORD STIMULATION (SCS) MARKET, BY GEOGRAPHY, 2012 – 2019 (USD THOUSAND) 39
TABLE 17 ISCHEMIA SEGMENT IN SPINAL CORD STIMULATION (SCS) MARKET,BY GEOGRAPHY, 2012 – 2019 (USD THOUSAND) 40
TABLE 18 DEEP BRAIN STIMULATION (DBS) MARKET IN SOUTH AFRICA, BY APPLICATION, 2012 – 2019 (USD THOUSAND) 42
TABLE 19 DEEP BRAIN STIMULATION (DBS) MARKET IN TURKEY, BY APPLICATION, 2012 – 2019 (USD THOUSAND) 43
TABLE 20 DEEP BRAIN STIMULATION (DBS) MARKET IN SAUDI ARABIA, BY APPLICATION, 2012 – 2019 (USD THOUSAND) 44
TABLE 21 PARKINSON’S DISEASE SEGMENT IN DEEP BRAIN STIMULATION (DBS) MARKET, BY GEOGRAPHY, 2012 – 2019 (USD THOUSAND) 45
TABLE 22 TREMOR SEGMENT IN DEEP BRAIN STIMULATION (DBS) MARKET,BY GEOGRAPHY, 2012 – 2019 (USD THOUSAND) 46
TABLE 23 DEPRESSION SEGMENT IN DEEP BRAIN STIMULATION (DBS) MARKET,BY GEOGRAPHY, 2013 - 2019 (USD THOUSAND) 47
TABLE 24 SACRAL NERVE STIMULATION (SNS) MARKET IN SOUTH AFRICA,BY APPLICATION, 2012 – 2019 (USD THOUSAND) 48
TABLE 25 SACRAL NERVE STIMULATION (SNS) MARKET IN TURKEY, BY APPLICATION,2012 – 2019 (USD THOUSAND) 49
TABLE 26 SACRAL NERVE STIMULATION (SNS) MARKET IN SAUDI ARABIA,BY APPLICATION, 2012 – 2019 (USD THOUSAND) 50
TABLE 27 URINARY INCONTINENCE SEGMENT IN SACRAL NERVE STIMULATION (SNS) MARKET, BY GEOGRAPHY, 2012 – 2019 (USD THOUSAND) 51
TABLE 28 FECAL INCONTINENCE SEGMENT IN SACRAL NERVE STIMULATION (SNS) MARKET, BY GEOGRAPHY, 2012 – 2019 (USD THOUSAND) 52
TABLE 29 VAGUS NERVE STIMULATION (VNS) MARKET IN SOUTH AFRICA,BY APPLICATION, 2012 – 2019 (USD THOUSAND) 54
TABLE 30 VAGUS NERVE STIMULATION (VNS) MARKET IN TURKEY, BY APPLICATION,2012 – 2019 (USD THOUSAND) 55
TABLE 31 VAGUS NERVE STIMULATION (VNS) MARKET IN SAUDI ARABIA,BY APPLICATION, 2012 – 2019 (USD THOUSAND) 56
TABLE 32 EPILEPSY SEGMENT IN VAGUS NERVE STIMULATION (VNS) MARKET,BY GEOGRAPHY, 2012 – 2019 (USD THOUSAND) 57
TABLE 33 GASTRIC ELECTRICAL STIMULATION (GES) MARKET IN SOUTH AFRICA,BY APPLICATION, 2012- 2019 (USD THOUSAND) 59
TABLE 34 GASTRIC ELECTRICAL STIMULATION (GES) MARKET IN TURKEY,BY APPLICATION, 2012 – 2019 (USD THOUSAND) 60
TABLE 35 GASTRIC ELECTRICAL STIMULATION (GES) MARKET IN SAUDI ARABIA,BY APPLICATION, 2012 – 2019 (USD THOUSAND) 61
TABLE 36 GASTROPARESIS SEGMENT IN GASTRIC ELECTRICAL STIMULATION (GES) MARKET, BY GEOGRAPHY, 2012 – 2019 (USD THOUSAND) 62
TABLE 37 BOSTON SCIENTIFIC CORPORATION: KEY FINANCIALS, BY SEGMENTS,2009 – 2013 (USD MILLION) 69
TABLE 38 BOSTON SCIENTIFIC: KEY FINANCIALS, BY GEOGRAPHY, 2009 – 2012 (USD MILLION) 70
TABLE 39 CYBERONICS, INC.: KEY FINANCIALS, 2009 - 2013 (USD MILLION) 72
TABLE 40 MEDTRONIC, INC. : KEY FINANCIALS, BY SEGMENTS, 2009 - 2013 (USD MILLION) 74
TABLE 41 MEDTRONIC, INC. : KEY FINANCIALS, 2009 - 2013 (USD MILLION) 75
TABLE 42 ST. JUDE MEDICAL: KEY FINANCIALS, BY SEGMENTS, 2011 - 2013 (USD MILLION) 77
TABLE 43 ST. JUDE MEDICAL: KEY FINANCIALS, BY GEOGRAPHY,2008 - 2013 (USD MILLION) 77
TABLE 44 UROPLASTY, INC. : KEY FINANCIALS, BY GEOGRAPHY,2011 - 2013 (USD MILLION) 81

LIST OF FIGURES

FIGURE 1 NEUROSTIMULATION/NEUROMODULATION MARKET IN SAUDI ARABIA, SOUTH AFRICA, AND TURKEY: SEGMENTATION & COVERAGE 10
FIGURE 2 INTERNAL NEUROSTIMULATION/NEUROMODULATION MARKET: INTEGRATED ECOSYSTEM 11
FIGURE 3 TOP-DOWN APPROACH 12
FIGURE 4 GLOBAL INTERNAL NEUROSTIMULATION/NEUROMODULATION MARKET: COMPARISON WITH PARENT MARKET, 2012 – 2018 (USD MILLION) 15
FIGURE 5 INTERNAL NEUROMODULATION/NEUROSTIMULATION MARKET,BY GEOGRAPHY, 2012 – 2019 (USD THOUSAND) 16
FIGURE 6 INTERNAL NEUROSTIMULATION/NEUROMODULATION MARKET IN SOUTH AFRICA, BY MODALITY, 2013–2019 (USD THOUSAND) 21
FIGURE 7 INTERNAL NEUROSTIMULATION/NEUROMODULATION MARKET IN TURKEY,BY MODALITY, 2013–2019 (USD THOUSAND) 22
FIGURE 8 INTERNAL NEUROSTIMULATION/NEUROMODULATION MARKET IN TURKEY,BY MODALITY, 2013–2019 (USD THOUSAND) 23
FIGURE 9 SPINAL CORD STIMULATION MARKET, BY GEOGRAPHY,2013–2019 (USD THOUSAND) 24
FIGURE 10 DEEP BRAIN STIMULATION MARKET, BY GEOGRAPHY,2013–2019 (USD THOUSAND) 26
FIGURE 11 SACRAL NERVE STIMULATION MARKET, BY GEOGRAPHY,2013–2019 (USD THOUSAND) 28
FIGURE 12 VAGUS NERVE STIMULATIONMARKET, BY GEOGRAPHY, 2013–2019 (USD MN) 30
FIGURE 13 GASTRIC ELECTRICAL STIMULATION MASKS MARKET, BY GEOGRAPHY,
2013–2019 (USD THOUSAND) 32
FIGURE 14 SPINAL CORD STIMULATION (SCS) MARKET IN SOUTH AFRICA, BY APPLICATION, 2012 – 2019 (USD THOUSAND) 34
FIGURE 15 SPINAL CORD STIMULATION (SCS) MARKET IN TURKEY, BY APPLICATION,2012 – 2019 (USD THOUSAND) 35
FIGURE 16 SPINAL CORD STIMULATION (SCS) MARKET IN SAUDI ARABIA, BY APPLICATION, 2012 – 2019 (USD THOUSAND) 36
FIGURE 17 CHRONIC PAIN SEGMENT IN SPINAL CORD STIMULATION (SCS) MARKET, BY GEOGRAPHY, 2012 – 2019 (USD THOUSAND) 37
FIGURE 18 FAILED BACK SURGERY SYNDROME SEGMENT IN SPINAL CORD STIMULATION (SCS) MARKET, BY GEOGRAPHY, 2012 – 2019 (USD THOUSAND) 38
FIGURE 19 ISCHEMIA SEGMENT IN SPINAL CORD STIMULATION (SCS) MARKET,BY GEOGRAPHY, 2012 – 2019 (USD THOUSAND) 39
FIGURE 20 DEEP BRAIN STIMULATION (DBS) MARKET IN SOUTH AFRICA, BY APPLICATION, 2012 – 2019 (USD THOUSAND) 41
FIGURE 21 DEEP BRAIN STIMULATION (DBS) MARKET IN TURKEY, BY APPLICATION,2012 – 2019 (USD THOUSAND) 42
FIGURE 22 DEEP BRAIN STIMULATION (DBS) MARKET IN SAUDI ARABIA, BY APPLICATION, 2012 – 2019 (USD THOUSAND) 43
FIGURE 23 PARKINSON’S DISEASE SEGMENT IN DEEP BRAIN STIMULATION (DBS) MARKET, BY GEOGRAPHY, 2012 – 2019 (USD THOUSAND) 44
FIGURE 24 TREMOR SEGMENT IN DEEP BRAIN STIMULATION (DBS) MARKET,BY GEOGRAPHY, 2012 – 2019 (USD THOUSAND) 45
FIGURE 25 DEPRESSION SEGMENT IN DEEP BRAIN STIMULATION (DBS) MARKET,BY GEOGRAPHY, 2012 – 2019 (USD THOUSAND) 46
FIGURE 26 SACRAL NERVE STIMULATION (SNS) MARKET IN SOUTH AFRICA, BY APPLICATION, 2012 – 2019 (USD THOUSAND) 48
FIGURE 27 SACRAL NERVE STIMULATION (SNS) MARKET IN TURKEY, BY APPLICATION,2012 – 2019 (USD THOUSAND) 49
FIGURE 28 SACRAL NERVE STIMULATION (SNS) MARKET IN SAUDI ARABIA, BY APPLICATION, 2012 – 2019 (USD THOUSAND) 50
FIGURE 29 URINARY INCONTINENCE SEGMENT IN SACRAL NERVE STIMULATION (SNS) MARKET, BY GEOGRAPHY, 2012 – 2019 (USD THOUSAND) 51
FIGURE 30 FECAL INCONTINENCE SEGMENT IN SACRAL NERVE STIMULATION (SNS) MARKET, BY GEOGRAPHY, 2012 – 2019 (USD THOUSAND) 52
FIGURE 31 VAGUS NERVE STIMULATION (VNS) MARKET IN SOUTH AFRICA, BY APPLICATION, 2012 – 2019 (USD THOUSAND) 54
FIGURE 32 VAGUS NERVE STIMULATION (VNS) MARKET IN TURKEY, BY APPLICATION,2012 – 2019 (USD THOUSAND) 55
FIGURE 33 VAGUS NERVE STIMULATION (VNS) MARKET IN SAUDI ARABIA, BY APPLICATION, 2012 – 2019 (USD THOUSAND) 56
FIGURE 34 EPILEPSY SEGMENT IN VAGUS NERVE STIMULATION (VNS) MARKET,BY GEOGRAPHY, 2012 – 2019 (USD THOUSAND) 57
FIGURE 35 GASTRIC ELECTRICAL STIMULATION (GES) MARKET IN SOUTH AFRICA, BY APPLICATION, 2012 – 2019 (USD THOUSAND) 59
FIGURE 36 GASTRIC ELECTRICAL STIMULATION (GES) MARKET IN TURKEY, BY APPLICATION,
2012 – 2019 (USD THOUSAND) 60
FIGURE 37 GASTRIC ELECTRICAL STIMULATION (GES) MARKET IN SAUDI ARABIA,BY APPLICATION, 2012 – 2019 (USD THOUSAND) 61
FIGURE 38 GASTROPARESIS SEGMENT IN GASTRIC ELECTRICAL STIMULATION (GES) MARKET, BY GEOGRAPHY, 2012 – 2019 (USD THOUSAND) 62
FIGURE 39 SOUTH AFRICA : SPINAL CORD STIMULATION , BY COMPANY, 2014 63
FIGURE 40 SAUDI ARABIA : SPINAL CORD STIMULATION , BY COMPANY, 2014 64
FIGURE 41 TURKEY : SPINAL CORD STIMULATION , BY COMPANY, 2014 64
FIGURE 42 SOUTH AFRICA : DEEP BRAIN STIMULATION , BY COMPANY, 2014 65
FIGURE 43 SAUDI ARABIA : DEEP BRAIN STIMULATION , BY COMPANY, 2014 65
FIGURE 44 TURKEY : DEEP BRAIN STIMULATION , BY COMPANY, 2014 66
FIGURE 45 SOUTH AFRICA : VAGUS NERVE STIMULATION , BY COMPANY, 2014 66
FIGURE 46 SAUDI ARABIA : VAGUS NERVE STIMULATION , BY COMPANY, 2014 67
FIGURE 47 TURKEY : VAGUS NERVE STIMULATION , BY COMPANY, 2014 67
FIGURE 48 INTERNAL NEUROSTIMULATION/ NEUROMODULATIONMARKET: COMPANY COVERAGE, BY PRODUCT, 2013 68

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